Scholar's profile
Leu, Yuwei
Leu, Yuwei
Associate Professor
Department of Biomedical Sciences
bioywl@ccu.edu.tw
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Scopus Data (view scopus profile)

Publication Achievements 2003 - 2024
Publication Index
Documents
37
CITATIONS
1768
H-INDEX
20
FWCI
0.45
Co-authors
144
Last Sync Date: 2025-08-17

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ORCID

Overview Research output Honors / Prize
Research output per year
2003
2024
34
Article
1
Letter
2
Review

Scopus

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A total of 34 data records, Page 1 / 4 , records per page, Go to page  
1 2 3 4

Publication

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  • 1 LOcating Non-Unique matched Tags (LONUT) to Improve the Detection of the Enriched Regions for ChIP-seq Data.
    Wang, Rui, Hsu, Hang-Kai, Blattler, Adam, Wang, Yisong, Lan, Xun, Wang, Yao, Hsu, Pei-Yin, Leu, Yu-Wei, Huang, Tim H. -M, Farnham, Peggy J and Jin, Victor X.
    PLOS ONE 2013 / 6
    Journal Article
  • 2 Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells
    Lee KD, Pai MY, Hsu CC, Chen CC, Chen YL, Chu PY, Lee CH, Chen LT, Chang JY, Huang TH, Hsiao SH and Leu YW
    Biochem Biophys Res 2012 / 6
    Journal Article
  • 3 Clustered DNA methylation changes in polycomb target genes in early-stage liver cancer
    Chen YL, Ko CJ, Lin PY, Chuang WL, Hsu CC, Chu PY, Pai MY, Chang CC, Kuo MH, Chu YR, Tung CH, Huang TH, Leu YW and Hsiao SH
    Biochem Biophys Res Commun. 2012 / 8
    Journal Article
  • 4 Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells
    Teng IW, Hou PC, Lee KD, Chu PY, Yeh KT, Jin VX, Tseng MJ, Tsai SJ, Chang YS, Wu CS, Sun HS, Tsai KD, Jeng LB, Nephew KP, Huang TH, Hsiao SH and Leu YW
    Cancer Research 2011 / 7
    Journal Article
  • 5 Identification of novel DNA methylation inhibitors via a two-Component reporter gene system.
    Yi-Shiuan Lin, Arthur Y. Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim H.-M. Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao
    Journal of Biomedical Science 2011 / 1
    Journal Article
  • 6 Functional characterization of Trip10 in cancer cell growth and survival.
    Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Chien-Min Chen, Pei-Yi Chu, Kun-Tu Yeh, Pearlly S. Yan, Yu-Sun Chang, Tim HM Huang and Shu-Huei Hsiao
    Journal of Biomedical Science 2011 / 2
    Journal Article
  • 7 DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochemical and Biophysical Research Communications
    Hsiao SH, Lee KD, Hsu CC, Tseng MJ, Jin VX, Sun WS, Hung YC, Yeh KT, Yan PS, Lai YY, Sun HS, Lu YJ, Chang YS, Tsai SJ, Huang TH and Leu YW
    Biochemical and Biophysical Research Communications 2010 / 9
    Journal Article
  • 8 Glutamate receptor, ionotropic, kainate 2 silencing by DNA hypermethylation possesses tumor suppressor function in gastric cancer.
    Wu CS, Lu YJ, Li HP, Hsueh C, Lu CY, Leu YW, Liu HP, Lin KH, Huang TH and Chang YS
    Int J Cancer 2010 / 6
    Journal Article
  • 9 Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer.
    Lu YJ, Wu CS, Li HP, Liu HP, Lu CY, Leu YW, Wang CS, Chen LC, Lin KH and Chang YS
    Genes Chromosomes Cancer 2010 / 5
    Journal Article
  • 10 核糖核酸干擾現象的技術及其在癌症治療上之運用
    朱旆億、蘇子誠、葉坤土、呂昱瑋、蕭淑惠
    Taiwan Medical Journal 2009 /
    Journal Article
1 2 3

Projects

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Teacher's name Research Units Year Project title Project position Commissioning unit Implementation period
Leu, Yuwei Department of Biomedical Sciences 2024 功能性辨別乳癌依存基因 PI 戴德森醫療財團法人嘉義基督教醫院 2024/11/01-2025/10/30
Leu, Yuwei Department of Biomedical Sciences 2024 113大專生計畫-於三陰性乳癌中表觀修飾 ENSA 及 ZNF484 基因 PI 國科會 2024/07/01-2025/02/28
Leu, Yuwei Department of Biomedical Sciences 2021 功能性探討受piRNA檢視的基因體維穩 PI 國科會 2021/08/01-2023/04/30
Leu, Yuwei Department of Biomedical Sciences 2021 探討表觀轉錄體調控在發育初期酒精接觸所引起的肝臟異常的角色 Co-PI 國科會 2021/08/01-2023/04/30
Leu, Yuwei Department of Biomedical Sciences 2020 探討表觀轉錄體失調在發育初期酒精接觸所引起的肝臟異常的角色 Co-PI 國科會 2020/08/01-2022/04/30
Leu, Yuwei Department of Biomedical Sciences 2019 以不正常piRNA表達偵測基因體失衡及非整倍基因體 PI 國科會 2019/08/01-2020/07/31
Leu, Yuwei Department of Biomedical Sciences 2019 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(3/3) Co-PI 國科會 2019/08/01-2021/01/31
Leu, Yuwei Department of Biomedical Sciences 2019 治療愷他命成癮及其所引起之精神疾患: NMDA受體與DNA甲基化的角色-愷他命成癮動物腦部及週血細胞細胞表觀基因體變異之探討(3/3) Co-PI 國科會 2019/08/01-2020/10/31
Leu, Yuwei Department of Biomedical Sciences 2018 PIWIL4和piRNA合成失活所誘發之非整倍基因體於骨髓間質幹細胞分化及癌化過程中所扮演的角色 PI 國科會 2018/08/01-2019/07/31
Leu, Yuwei Department of Biomedical Sciences 2018 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(2/3) Co-PI 國科會 2018/08/01-2021/01/31
Leu, Yuwei Department of Biomedical Sciences 2017 106大專生計畫-PIWIL4重新表達以維穩基因體及細胞生理 PI 國科會 2017/07/01-2018/02/28
Leu, Yuwei Department of Biomedical Sciences 2017 治療愷他命成癮及其所引起之精神疾患: NMDA受體與DNA甲基化的角色-愷他命成癮動物腦部及週血細胞細胞表觀基因體變異之探討(1/3) Co-PI 國科會 2017/08/01-2018/07/31
Leu, Yuwei Department of Biomedical Sciences 2017 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(1/3) Co-PI 國科會 2017/08/01-2021/01/31
Leu, Yuwei Department of Biomedical Sciences 2016 利用HIC1和RassF1A甲基化觀測系統以檢定無糖人蔘皂甘（aPPD）之去甲基化和抑癌成效 PI 國科會 2016/08/01-2017/07/31
Leu, Yuwei Department of Biomedical Sciences 2016 探討發育初期酒精的接觸對腦細胞表觀基因調控系統之長期影響 Co-PI 國科會 2016/08/01-2017/07/31
Leu, Yuwei Department of Biomedical Sciences 2015 大專生計畫-L1TD1 methylation is essential for tumoral growth PI 國科會 2015/07/01-2016/02/28
Leu, Yuwei Department of Biomedical Sciences 2015 大專生計畫-PIWIL4對基因甲基化與基因組穩定性的必要性 PI 國科會 2015/07/01-2016/02/28
Leu, Yuwei Department of Biomedical Sciences 2015 探討表觀基因調控於酒精對腦細胞長期影響之角色 Co-PI 國科會 2015/08/01-2016/07/31
Leu, Yuwei Department of Biomedical Sciences 2015 台加（MOST-CIHR-IG）表觀基因體學雙邊研討會」暨CanadianGE3LSand Health Services and Policy Research Conference PI 國科會 2015/04/17-2015/04/25
Leu, Yuwei Department of Biomedical Sciences 2015 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(3/3) PI 國科會 2015/08/01-2016/07/31
Leu, Yuwei Department of Biomedical Sciences 2014 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(2/3) PI 國科會 2014/08/01-2016/07/31
Leu, Yuwei Department of Biomedical Sciences 2014 活體及活細胞中篩選並擇定去氧去醣核酸去甲基化藥物 PI 財團法人國家衛生研究院 2014/01/01-2014/12/31
Leu, Yuwei Department of Biomedical Sciences 2013 活體及活細胞中篩選並擇定去氧核醣核酸去甲基化藥物 PI 財團法人國家衛生研究院 2013/01/01-2013/12/31
Leu, Yuwei Department of Biomedical Sciences 2013 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(1/3) PI 國科會 2013/08/01-2016/07/31
Leu, Yuwei Department of Biomedical Sciences 2012 AFM力學量測所需蛋白質樣品-技術服務 PI 財團法人工業技術研究院 2012/11/01-2013/03/20
Leu, Yuwei Department of Biomedical Sciences 2012 解析不同Notch受體對3T3-L1脂肪前驅細胞分化的多樣化影響 Co-PI 國科會 2012/08/01-2013/07/31
Leu, Yuwei Department of Biomedical Sciences 2012 探討酒精所引起的表觀基因性修飾對腦及間質幹細胞發育之影響 Co-PI 國科會 2012/08/01-2013/12/31
Leu, Yuwei Department of Biomedical Sciences 2011 探討對位性基因體修飾於酒精所引起之腦及間質幹細胞異常發育的作用機轉 Co-PI 國科會 2011/08/01-2012/07/31
Leu, Yuwei Department of Biomedical Sciences 2010 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(3/3) PI 國科會 2010/08/01-2011/07/31
Leu, Yuwei Department of Biomedical Sciences 2010 大專生計畫－Targeted Methylation of Viral Promoter PI 國科會 2010/07/01-2011/02/28
Leu, Yuwei Department of Biomedical Sciences 2009 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(2/3) PI 國科會 2009/08/01-2011/07/31
Leu, Yuwei Department of Biomedical Sciences 2009 功能性對位性基因體法以建立癌化模式(1/2) PI 國科會 2009/05/01-2010/04/30
Leu, Yuwei Department of Biomedical Sciences 2008 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(1/3) PI 國科會 2008/08/01-2011/07/31
Leu, Yuwei Department of Biomedical Sciences 2008 大專生計畫-利用HOXC13的甲基化以鑑別及標定雌激素受體不表達之乳癌 PI 國科會 2008/07/01-2009/02/28
Leu, Yuwei Department of Biomedical Sciences 2008 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(3/3) PI 國科會 2008/05/01-2009/04/30
Leu, Yuwei Department of Biomedical Sciences 2007 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(3/3) PI 國科會 2007/08/01-2008/07/31
Leu, Yuwei Department of Biomedical Sciences 2007 探討酒精所引起的對位性基因修飾對腦部發育的影響 Co-PI 國科會 2007/08/01-2008/07/31
Leu, Yuwei Department of Biomedical Sciences 2007 CASP8AP2 DNA甲基化在癌化及骨髓間質幹細胞分化過程中的調控 PI 國科會 2007/07/01-2008/02/28
Leu, Yuwei Department of Biomedical Sciences 2007 ENSA做為抑癌基因可能性之探討 PI 國科會 2007/07/01-2008/02/28
Leu, Yuwei Department of Biomedical Sciences 2007 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(2/3) PI 國科會 2007/05/01-2008/04/30
Leu, Yuwei Department of Biomedical Sciences 2006 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(1/3) PI 國科會 2006/05/01-2007/04/30
Leu, Yuwei Department of Biomedical Sciences 2006 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(2/3) PI 國科會 2006/08/01-2007/07/31
Leu, Yuwei Department of Biomedical Sciences 2006 短干擾性核糖核酸引發長效性基因默化機制之探討 PI 國科會 2006/07/01-2007/02/28
Leu, Yuwei Department of Biomedical Sciences 2006 Trip10基因在乳癌轉移過程中對位性基因型的調控 PI 國科會 2006/07/01-2007/02/28
Leu, Yuwei Department of Biomedical Sciences 2006 利用293 HEK纖母細胞來研究活化型Notch1抑制癌化的分子機制 Co-PI 國科會 2006/08/01-2007/07/31
Leu, Yuwei Department of Biomedical Sciences 2006 探討酒精以對位性基因修飾所造成的中樞神經異常 Co-PI 國科會 2006/08/01-2007/07/31
Leu, Yuwei Department of Biomedical Sciences 2005 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(1/3) PI 國科會 2005/08/01-2006/07/31
Leu, Yuwei Department of Biomedical Sciences 2005 酒精對神經細胞進行對位性遺傳性質修飾之探討 Co-PI 國科會 2005/08/01-2006/07/31
Leu, Yuwei Department of Biomedical Sciences 2005 功能性對位基因體法的應用與乳癌擴展之鑑定 PI 國科會 2005/01/01-2005/07/31

Patents

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Patents Apply Date Apply Number Patent Number Patent Country Inventor
決定一細胞中的一個標的基因之生物功能 2008/06/11 97121717 I364460 R.O.C Yu-Wei, Leu
決定一細胞中的一個標的基因之生物功能 2008/06/09 12/135,540 US 8,067,163 B2 U.S.A. Yu-Wei, Leu
藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況 2008/06/11 97121718 I353254 R.O.C Yu-Wei, Leu
藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況 2008/06/09 12/135,565 US 9,023,819 B2 U.S.A. Yu-Wei, Leu
用於哺乳動物細胞的三元件基因表現報導系統及其應用 2009/10/16 98135114 I393779 R.O.C Yu-Wei, Leu
Source：Chung Cheng Academic Achievements Information System