Scholar's profile
Leu, Yuwei
Associate Professor
Scopus Data (view scopus profile)
Publication Achievements
2003 - 2024
Publication Index
Documents
37
CITATIONS
1808
H-INDEX
20
FWCI
0.45
Co-authors
144
Last Sync Date: 2026-04-05
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Scopus
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1Letter
Quantitative competitive allele-specific taqman duplex PCR (qCAST-duplex PCR) assay: A refined method for highly sensitive and specific detection of JAK2V617f mutant allele burdens
Haematologica 2018, 103 (10) , e450-e4547Citation
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Publication
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1 Piwi-Interacting RNAs Safeguard Somatic Genome Integrity.Frontiers in Cancer Science (FCS) 2025, NUS University Cultural Centre, Singapore 2025 / 0Seminar Paper
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2 Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells.J Physiol Invest 2024 / 0Journal Article
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3 Dysregulated HIC1 and RassF1A expression alters the cell cytoskeleton and exosomal Piwi-interacting RNA.Biochem. Biophys. Res. Commun. 2022 / 0Journal Article
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4 Profile of Histone H3 Lysine 4 Trimethylation and the Effect of Lipopolysaccharide/Immune Complex-Activated Macrophages on Endotoxemia.Frontiers Immunology 2019 / 0Journal Article
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5 Inverse Correlation between Methylation and Expression of the Delta-like Ligands (DLL1) Gene in Gastric Cancer.Chinese J. of Physiology 2018 / 0Journal Article
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6 Quantitative competitive allele-specific TaqMan duplex PCR (qCAST-Duplex PCR) assay: a refined method for highly sensitive and specific detection of JAK2V617F mutant allele burdensHaematologica 2018 / 0Journal Article
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7 HIC1 and RassF1A methylation attenuates tubulin expression and cell stiffness in cancer.Int. J. Mol. Sci. 2018 / 0Journal Article
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8 Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer.Annals of Surgical Oncology 2017 / 0Journal Article
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9 JAK2V617F influences epigenomic changes in myeloproliferative neoplasms.Biochem. Biophys. Res. Commun. 2017 / 0Journal Article
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10 Aberrant Let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms.Haematologica 2017 / 0Journal Article
Projects
Print-friendly| Teacher's name | Research Units | Year | Project title | Project position | Commissioning unit | Implementation period |
|---|---|---|---|---|---|---|
| Leu, Yuwei | Department of Biomedical Sciences | 2024 | 功能性辨別乳癌依存基因 | PI | 戴德森醫療財團法人嘉義基督教醫院 | 2024/11/01-2025/10/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2024 | 113大專生計畫-於三陰性乳癌中表觀修飾 ENSA 及 ZNF484 基因 | PI | 國科會 | 2024/07/01-2025/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2021 | 功能性探討受piRNA檢視的基因體維穩 | PI | 國科會 | 2021/08/01-2023/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2021 | 探討表觀轉錄體調控在發育初期酒精接觸所引起的肝臟異常的角色 | Co-PI | 國科會 | 2021/08/01-2023/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2020 | 探討表觀轉錄體失調在發育初期酒精接觸所引起的肝臟異常的角色 | Co-PI | 國科會 | 2020/08/01-2022/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2019 | 以不正常piRNA表達偵測基因體失衡及非整倍基因體 | PI | 國科會 | 2019/08/01-2020/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2019 | 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(3/3) | Co-PI | 國科會 | 2019/08/01-2021/01/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2019 | 治療愷他命成癮及其所引起之精神疾患: NMDA受體與DNA甲基化的角色-愷他命成癮動物腦部及週血細胞細胞表觀基因體變異之探討(3/3) | Co-PI | 國科會 | 2019/08/01-2020/10/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2018 | PIWIL4和piRNA合成失活所誘發之非整倍基因體於骨髓間質幹細胞分化及癌化過程中所扮演的角色 | PI | 國科會 | 2018/08/01-2019/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2018 | 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(2/3) | Co-PI | 國科會 | 2018/08/01-2021/01/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2017 | 106大專生計畫-PIWIL4重新表達以維穩基因體及細胞生理 | PI | 國科會 | 2017/07/01-2018/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2017 | 治療愷他命成癮及其所引起之精神疾患: NMDA受體與DNA甲基化的角色-愷他命成癮動物腦部及週血細胞細胞表觀基因體變異之探討(1/3) | Co-PI | 國科會 | 2017/08/01-2018/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2017 | 探討發育初期酒精的接觸、腸道菌、表觀基因調控的交互作用對腦部之影響(1/3) | Co-PI | 國科會 | 2017/08/01-2021/01/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2016 | 利用HIC1和RassF1A甲基化觀測系統以檢定無糖人蔘皂甘（aPPD）之去甲基化和抑癌成效 | PI | 國科會 | 2016/08/01-2017/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2016 | 探討發育初期酒精的接觸對腦細胞表觀基因調控系統之長期影響 | Co-PI | 國科會 | 2016/08/01-2017/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2015 | 大專生計畫-L1TD1 methylation is essential for tumoral growth | PI | 國科會 | 2015/07/01-2016/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2015 | 大專生計畫-PIWIL4對基因甲基化與基因組穩定性的必要性 | PI | 國科會 | 2015/07/01-2016/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2015 | 探討表觀基因調控於酒精對腦細胞長期影響之角色 | Co-PI | 國科會 | 2015/08/01-2016/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2015 | 台加（MOST-CIHR-IG）表觀基因體學雙邊研討會」暨CanadianGE3LSand Health Services and Policy Research Conference | PI | 國科會 | 2015/04/17-2015/04/25 |
| Leu, Yuwei | Department of Biomedical Sciences | 2015 | 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(3/3) | PI | 國科會 | 2015/08/01-2016/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2014 | 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(2/3) | PI | 國科會 | 2014/08/01-2016/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2014 | 活體及活細胞中篩選並擇定去氧去醣核酸去甲基化藥物 | PI | 財團法人國家衛生研究院 | 2014/01/01-2014/12/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2013 | 活體及活細胞中篩選並擇定去氧核醣核酸去甲基化藥物 | PI | 財團法人國家衛生研究院 | 2013/01/01-2013/12/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2013 | 間質幹細胞分化為肝組織及其衍生癌化之表觀基因性普查(1/3) | PI | 國科會 | 2013/08/01-2016/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2012 | AFM力學量測所需蛋白質樣品-技術服務 | PI | 財團法人工業技術研究院 | 2012/11/01-2013/03/20 |
| Leu, Yuwei | Department of Biomedical Sciences | 2012 | 解析不同Notch受體對3T3-L1脂肪前驅細胞分化的多樣化影響 | Co-PI | 國科會 | 2012/08/01-2013/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2012 | 探討酒精所引起的表觀基因性修飾對腦及間質幹細胞發育之影響 | Co-PI | 國科會 | 2012/08/01-2013/12/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2011 | 探討對位性基因體修飾於酒精所引起之腦及間質幹細胞異常發育的作用機轉 | Co-PI | 國科會 | 2011/08/01-2012/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2010 | 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(3/3) | PI | 國科會 | 2010/08/01-2011/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2010 | 大專生計畫－Targeted Methylation of Viral Promoter | PI | 國科會 | 2010/07/01-2011/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2009 | 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(2/3) | PI | 國科會 | 2009/08/01-2011/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2009 | 功能性對位性基因體法以建立癌化模式(1/2) | PI | 國科會 | 2009/05/01-2010/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2008 | 對位性基因體法以鑑別暨標定雌性素受體不表達之乳癌(1/3) | PI | 國科會 | 2008/08/01-2011/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2008 | 大專生計畫-利用HOXC13的甲基化以鑑別及標定雌激素受體不表達之乳癌 | PI | 國科會 | 2008/07/01-2009/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2008 | 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(3/3) | PI | 國科會 | 2008/05/01-2009/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2007 | 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(3/3) | PI | 國科會 | 2007/08/01-2008/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2007 | 探討酒精所引起的對位性基因修飾對腦部發育的影響 | Co-PI | 國科會 | 2007/08/01-2008/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2007 | CASP8AP2 DNA甲基化在癌化及骨髓間質幹細胞分化過程中的調控 | PI | 國科會 | 2007/07/01-2008/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2007 | ENSA做為抑癌基因可能性之探討 | PI | 國科會 | 2007/07/01-2008/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2007 | 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(2/3) | PI | 國科會 | 2007/05/01-2008/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | 成體幹細胞之分化及癌化間對位性基因體關聯性之探討(1/3) | PI | 國科會 | 2006/05/01-2007/04/30 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(2/3) | PI | 國科會 | 2006/08/01-2007/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | 短干擾性核糖核酸引發長效性基因默化機制之探討 | PI | 國科會 | 2006/07/01-2007/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | Trip10基因在乳癌轉移過程中對位性基因型的調控 | PI | 國科會 | 2006/07/01-2007/02/28 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | 利用293 HEK纖母細胞來研究活化型Notch1抑制癌化的分子機制 | Co-PI | 國科會 | 2006/08/01-2007/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2006 | 探討酒精以對位性基因修飾所造成的中樞神經異常 | Co-PI | 國科會 | 2006/08/01-2007/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2005 | 對位基因性修飾作為乳癌進程痕跡暨其檢定之生物標記的建立及評量(1/3) | PI | 國科會 | 2005/08/01-2006/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2005 | 酒精對神經細胞進行對位性遺傳性質修飾之探討 | Co-PI | 國科會 | 2005/08/01-2006/07/31 |
| Leu, Yuwei | Department of Biomedical Sciences | 2005 | 功能性對位基因體法的應用與乳癌擴展之鑑定 | PI | 國科會 | 2005/01/01-2005/07/31 |
Patents
Print-friendly| Patents | Apply Date | Apply Number | Patent Number | Patent Country | Inventor |
|---|---|---|---|---|---|
| 決定一細胞中的一個標的基因之生物功能 | 2008/06/11 | 97121717 | I364460 | R.O.C | Yu-Wei, Leu |
| 決定一細胞中的一個標的基因之生物功能 | 2008/06/09 | 12/135,540 | US 8,067,163 B2 | U.S.A. | Yu-Wei, Leu |
| 藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況 | 2008/06/11 | 97121718 | I353254 | R.O.C | Yu-Wei, Leu |
| 藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況 | 2008/06/09 | 12/135,565 | US 9,023,819 B2 | U.S.A. | Yu-Wei, Leu |
| 用於哺乳動物細胞的三元件基因表現報導系統及其應用 | 2009/10/16 | 98135114 | I393779 | R.O.C | Yu-Wei, Leu |
Source：Chung Cheng Academic Achievements Information System